Resources

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Advances

Aderans Research Institute Hair Regeneration PDF outlining describing Ji Gami process and timeline.

Hair transplantation is limited by the amount of donor hair and cannot regenerate additional hair. Cell therapy is the next game changing platform for hair regeneration.

Histogen Reports Lasting Effects In Small Study of Baldness Treatment 

Histogen has announced a one-year follow-up study of 24 patients who participated in an experiment using its Hair Stimulating Complex, or HSC, shows “statistically significant” new hair growth. Participants in the study, which was done in Honduras, also showed a statistically significant increase in hair density.

Follica Gets New CEO, Gears Up for More (Hair and Business) Growth

“There’s just a lot of excitement with regard to the science, and to the progress that’s been made,” Ju says of Follica’s work to date.

About TrichoScience  Ongoing

The TrichoScience proprietary hair cell replication procedure has shown promising results in laboratory test models. Based on these results, the TrichoScience team has started development of a human clinical trial program.

Aderans Research Treats One-Hundredth Subject in Clinical Study 

Aderans Research Institute Inc. (ARI) recently achieved a significant milestone in its Phase 2 clinical study of cell-based hair regeneration, treating the trial’s 100th subject.

Biotech Turns to Hair Loss Research  "They're throwing an arsenal of high-tech tools at the condition: genome studies, stem cell stimulation, gene therapy, a type of tissue engineering often called "hair cloning" and even robotics.

Gene Discovery May Lead to New Baldness Drugs  Reuters Health News

"There is a very good chance of developing a therapy to treat hair loss based on this finding," the study's leader Regina Betz, a researcher at the Institute of Human Genetics, said.

 

Hair and Scalp Surgery

Art of Repair in Surgical Hair Restoration- part one, part two  Bernstein R.M.; Rassman W.R.; Rashid N.; Shiell R.C. Dermatologic Surgery, Volume 28, Number 10, October 2002 , pp. 873-893(21)

Summary: Patients undergo additional surgeries to try and correct damage caused by unethical practitioners.

The use of small grafts alone does not protect the patient from poor work. Errors in surgical and aesthetic judgment, performing procedures on non-candidate patients, and the failure to communicate successfully with patients about realistic expectations, remain major problems.

Hair Replacement Surgery, Hair Transplantation  WebMD article, Jorge de la Torre MD, Gary D Monheit, MD, periodically updated 

Summary: A history and overview of this type of surgery.

A new sobering conservative view is emerging in the field of hair transplantation: the surgeon should evaluate the patient both regarding the improvement he or she can provide in the immediate future and for long-term results. Too much emphasis has been placed on immediate coverage and appearance and not enough attention paid to the long-lasting effects of this permanent procedure.

Hair Transplantation Associated with Various Complications  Dow B. Stough, Clinical Assistant Professor of Dermatology, University of Arkansas 

Summary: Observations by Dow B. Stough M.D. 

Poor growth of the graft is unpredictable and has been reported with every technique ever utilized in hair transplant surgery. Young patients may have unrealistic expectations, hoping that hair transplantation will help them achieve extremely dense coverage similar to that of a nonbalding man. Such an outcome is not possible because the newer transplantation techniques do not generally allow for dense coverage. Additionally, donor hair, although generally programmed to remain throughout life, does thin over time.

Hair Loss: Procedures to Avoid  WebMD.com article 

Summary: Many physicians in this country and abroad perform outdated and even dangerous hair restoration techniques.

Scalp reduction problems include: Accelerated hair loss, more than the natural course your hair would take. This hair loss can occur within just weeks or months and often doesn't return. An unnatural appearance because the direction of hair growth is altered. Infection. Hemorrhaging and hematoma (blood pooling). Stretch back, a problem in almost 100% of scalp reduction cases...

Strip Excision Donor Area Complications  Hairsite.com article

Summary: Observations by Jerzy Kolasinski M.D.,Ph.D

Excerpts: Most frequently occurring complications in the donor area include: early and late hemorrhages, infections, skin necrosis, pain and paresthesia in the wound and scar area, visible scarring, wide scars, alopecia in the scar area.

 

Follicular Unit Extraction: Minimally Invasive Surgery for Hair Transplantation

Rassman W.R; Bernstein R.M; McClellan R; Jones R; Worton E; Uyttendaele H, Dermatologic Surgery 2002; 28: 720-728

Summary: Describes the FUE technique.

Follicular Unit Extraction is a minimally invasive approach to hair transplantation that obviates the need for a linear donor incision. This technique can serve as an important alternative to traditional hair transplantation in certain patients.

Follicular Unit Extraction
William R. Rassman, James Harris, Robert M. Bernstein, In: Haber RS, Stough DB, editors: Hair Transplantation, Chapter 17. Elsevier Saunders, 2006: 133-137

Summary: Indications and Contraindications for FUE. The "Two-Step" and "Three-Step" Techniques are discussed.
The promise of an almost scarless surgery is enticing to both patient and surgeon. Contraindications for FUE include: 1. Inexperience in performing FUE techniques 2. Unavailability of proper instrumentation 3. Inadequate and uninformed patient consent 4. Unrealistic patient expectations 5. Inadequate donor supply 6. Scarring that makes both the two- and three-step procedures problematic.

The following three articles are available in full text through Medline (check your local university or medical school library)

Hair transplantation: management of donor area (abstract) Gerard E. Seery M.D.
Dermatologic Surgery 2002 Feb;28(2):136-42.

Summary: Discussion of methods and problems involved with donor harvesting. 

The simplest part of hair transplantation, at least in theory, is the removal of the donor strip and closure of the resultant defect. Unfortunately, however, the improvements that have taken place in hair transplantation in general have not spilled over into improved donor area outcomes. Unsightly donor scars and fibrosis are still not only with us, but are possibly even more pervasive than ever. One explanation given for deteriorated donor sites is the harvesting of relatively greater numbers of grafts.  

Surgical Anatomy of the Scalp (abstract) Gerard E. Seery M.D.

Dermatologic Surgery 2002 Feb;28(7):581–587

Summary: A description of the anatomy of the scalp with surgical implications.

The goal of complication-free scalp surgery remains elusive. Wide unsightly scars, stretch-atrophied hypesthetic, poorly vascularized tissues and distorted hair patterns are still commonly seen and appear to be largely refractory to remedial surgery.

Local anesthesia in hair transplantation (abstract) Seager DJ, Simmons C., Dermatologic Surgery 2002 Apr;28(4):320-8

Summary: Reviews the agents and techniques of local anesthesia as applied to hair transplantation. Discusses the dangers of infiltrating too much anesthetic; harming vessels and nerves with needles; anesthetic toxicity and intravascular instillation of anesthetic solution.

Complications of nerve blocks include laceration of nerves and vessels, and intravascular infiltration. The needleless injector is used to create wheals through which a conventional needle can painlessly penetrate the skin. However, this still will not eliminate infiltration pain.